Triterpenoids from Ainsliaea latifolia and Their Cyclooxyenase-2 (COX-2) Inhibitory Activities
-
Published:2019-11-30
Issue:1
Volume:10
Page:13-21
-
ISSN:2192-2195
-
Container-title:Natural Products and Bioprospecting
-
language:en
-
Short-container-title:Nat. Prod. Bioprospect.
Author:
Yuan Wen-Lin, Dong Xue-Yun, Huang Zheng-Rui, Xiao Si-Jia, Ye Ji, Tian Xin-Hui, Li Hui-Liang, Shen Yun-HengORCID, Zhang Wei-Dong
Abstract
Abstract
Eight new triterpenoids were isolated from Ainsliaea latifolia. The structures of these compounds were elucidated by interpretation of spectroscopic data, including HRESIMS and NMR data. Compounds 4–6 are identified as rare trinorcucurbitane or tetranorcucurbitane triterpenoids. The absolute configurations of compounds 1 and 2 were confirmed by Snatzke’s method. All compounds were evaluated for their inhibition against cyclooxyenase-2 (COX-2), in which compound 4 showed significant inhibitory effect against COX-2 with IC50 value of 3.98 ± 0.32 μM, comparable to that of positive control NS-398 (IC50 4.14 ± 0.28 μM).
Graphic Abstract
Funder
National Natural Science Foundation of China National Major Project of China The Key Research and Development Program of China Professor of Chang Jiang Scholars Program Scientific Foundation of Shanghai China Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,Plant Science,Pharmacology,Toxicology,Biochemistry,Food Science,Analytical Chemistry
Reference13 articles.
1. Z.J. Wu, X.K. Xu, H.W. Zeng, Y.H. Shen, J.M. Tian, J. Su, H.L. Li, L. Shan, R.H. Liu, W.D. Zhang, Planta Med. 77, 1545–1550 (2011) 2. Y. Wang, Y.H. Shen, H.Z. Jin, J.J. Fu, X.J. Hu, J.J. Qin, J.H. Liu, M. Chen, S.K. Yan, W.D. Zhang, Org. Lett. 10, 5517–5520 (2008) 3. Z.J. Wu, X.K. Xu, Y.H. Shen, J. Su, J.M. Tian, S. Liang, H.L. Li, R.H. Liu, W.D. Zhang, Org. Lett. 10, 2397–2400 (2008) 4. F. Hilmi, J. Gertsch, P. Bremner, S. Valovic, M. Heinrich, O. Sticher, J. Heilmann, Bioorgan. Med. Chem. 11, 3659–3663 (2003) 5. M.T. Lindenmeyer, A. Hrenn, C. Kern, V. Castro, R. Murillo, S. Müller, S. Laufer, J. Schulte-Mönting, B. Siedle, I. Merfort, Bioorgan. Med. Chem. 14, 2487–2497 (2006)
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|