Author:
Li Fengli,Gu Saisai,Zhang Sitian,Mo Shuyuan,Guo Jieru,Hu Zhengxi,Zhang Yonghui
Abstract
AbstractThree new amide derivatives (alteralkaloids A–C, 1–3) and three known alkaloids (4–6) were afforded after phytochemical investigation of fungus Alternaria brassicicola. The structures of these compounds were confirmed by NMR spectroscopic and HRESIMS data. Furthermore, the absolute configuration of 1 was determined using the single-crystal X-ray diffraction analysis. Compounds 1–3 belong to a class of amide derivatives that have not been found in nature before, sharing the same characteristic signals of the butyl moiety and amide group. These isolated compounds mentioned above were tested for the cytotoxic activity.
Graphical Abstract
Funder
National Natural Science Foundation of China
the National Program for Support of Topnotch Young Professionals
the National Key R&D Program of China
National Natural Science Foundation for Distinguished Young Scholars
the Innovative Research Groups of the National Natural Science Foundation of China
Academic Frontier Youth Team of HUST
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,Plant Science,Pharmacology,Toxicology,Biochemistry,Food Science,Analytical Chemistry