Three new amide derivatives from the fungus Alternaria brassicicola

Author:

Li Fengli,Gu Saisai,Zhang Sitian,Mo Shuyuan,Guo Jieru,Hu Zhengxi,Zhang Yonghui

Abstract

AbstractThree new amide derivatives (alteralkaloids A–C, 13) and three known alkaloids (46) were afforded after phytochemical investigation of fungus Alternaria brassicicola. The structures of these compounds were confirmed by NMR spectroscopic and HRESIMS data. Furthermore, the absolute configuration of 1 was determined using the single-crystal X-ray diffraction analysis. Compounds 13 belong to a class of amide derivatives that have not been found in nature before, sharing the same characteristic signals of the butyl moiety and amide group. These isolated compounds mentioned above were tested for the cytotoxic activity. Graphical Abstract

Funder

National Natural Science Foundation of China

the National Program for Support of Topnotch Young Professionals

the National Key R&D Program of China

National Natural Science Foundation for Distinguished Young Scholars

the Innovative Research Groups of the National Natural Science Foundation of China

Academic Frontier Youth Team of HUST

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,Plant Science,Pharmacology,Toxicology,Biochemistry,Food Science,Analytical Chemistry

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