Inhibition of ferrochelatase and accumulation of porphyrins in mouse hepatocyte cultures exposed to porphyrinogenic chemicals

Author:

Brady Angela M.,Lock Edward A.

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Reference28 articles.

1. Abbritti G, De Matteis F (1971) Decreased levels of cytochrome P-450 and catalase in hepatic porphyria caused by substituted acetamides and barbiturates. Importance of the allyl group in the molecule of the active drugs. Chem Biol Interact 4: 281–286

2. Brady AM, Lock EA (1990) Induction of porphyria in primary mouse and rat hepatocyte cultures. Toxicologist 10 [1]: 296

3. Cole SPC, Massey TE, Marks GS, Racz WJ (1981a) Effects of porphyrin-inducing drugs on ferrochelatase activity in isolated mouse hepatocytes. Can J Physiol Pharmacol 59: 1155–1158

4. Cole SPC, Whitney RA, Marks GS (1981b) Ferrochelatase-inhibitory and porphyrin-inducing properties of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine and its analogues in chick embryo liver cells. Mol Pharmacol 20: 295–403

5. Cole SPC, Zelt DT, Marks GS (1981c) Comparison of the effects of griseofulvin and 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on ferrochelatase activity in chick embryo liver. Mol Pharmacol 19: 477–480

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