Author:
Liang Wenjia,Yu Qiaowen,Wang Wenjun,Dhollander Thijs,Suluba Emmanuel,Li Zhuoran,Xu Feifei,Hu Yang,Tang Yuchun,Liu Shuwei
Abstract
AbstractThe superior longitudinal fasciculus (SLF) is a complex associative tract comprising three distinct subdivisions in the frontoparietal cortex, each of which has its own anatomical connectivity and functional roles. However, many studies on white matter development, hampered by limitations of data quality and tractography methods, treated the SLF as a single entity. The exact anatomical trajectory and developmental status of each sub-bundle of the human SLF in neonates remain poorly understood. Here, we compared the morphological and microstructural characteristics of each branch of the SLF at two ages using diffusion MRI data from 40 healthy neonates and 40 adults. A multi-shell multi-tissue constrained spherical deconvolution (MSMT-CSD) algorithm was used to ensure the successful separation of the three SLF branches (SLF I, SLF II and SLF III). Then, between-group differences in the diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) metrics were investigated in all the SLF branches. Meanwhile, Mahalanobis distances based on all the diffusion metrics were computed to quantify the maturation of neonatal SLF branches, considering the adult brain as the reference. The SLF branches, excluding SLF II, had similar fibre morphology and connectivity between the neonatal and adult groups. The Mahalanobis distance values further supported the notion of heterogeneous maturation among SLF branches. The greatest Mahalanobis distance was observed in SLF II, possibly indicating that it was the least mature. Our findings provide a new anatomical basis for the early diagnosis and treatment of diseases caused by abnormal neonatal SLF development.
Funder
National Natural Science Foundation of China
Major Scientific and Technological Innovation Project of Shandong Province
Natural Science Foundation of Shandong Province
Publisher
Springer Science and Business Media LLC
Subject
Histology,General Neuroscience,Anatomy
Cited by
3 articles.
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