How Aggregate Safety Assessment Planning Supports Investigational New Drug Safety Reporting Decisions

Author:

Hendrickson Barbara A.ORCID,McShea Cynthia,Ball Greg,Talbot Susan

Publisher

Springer Science and Business Media LLC

Reference19 articles.

1. International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH). ICH E2A: clinical safety data management: definitions and standards for expedited reporting; 1994. https://database.ich.org/sites/default/files/E2A_Guideline.pdf.

2. U.S. Food and Drug Administration. Investigational new drug safety reporting requirements for human drugs and biological products and safety reporting requirements for bioavailability and bioequivalence studies in humans: final rule; 2010. https://www.govinfo.gov/content/pkg/FR-2010-09-29/pdf/2010-24296.pdf.

3. U.S. Food and Drug Administration. Guidance for industry and investigators: safety reporting requirements for INDs and BA/BE studies; 2012. https://www.fda.gov/media/79394/download.

4. Jarow JP, Casak S, Chuk M, et al. The majority of expedited investigational new drug safety reports are uninformative. Clin Cancer Res. 2016;22(9):2111–3.

5. US Food and Drug Administration. Draft guidance for industry: sponsor responsibilities—safety reporting requirements and safety assessment for IND and bioavailability/ bioequivalence studies; 2021. https://www.fda.gov/media/150356/download. Accessed 10 Oct 2023.

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