Combined, yet separate: cocktails of carriers (not drugs) for actinium-225 α-particle therapy of solid tumors expressing moderate-to-low levels of targetable markers-Reference-Cited by-同舟云学术

Combined, yet separate: cocktails of carriers (not drugs) for actinium-225 α-particle therapy of solid tumors expressing moderate-to-low levels of targetable markers

Published:2024-04-20 Issue:9 Volume:51 Page:2649-2662
ISSN:1619-7070
Container-title:European Journal of Nuclear Medicine and Molecular Imaging
language:en
Short-container-title:Eur J Nucl Med Mol Imaging

Author:

Nair Rajiv Ranjit,Prasad Aprameya,Bhatavdekar Omkar,Sarkar Aira,Gabrielson Kathleen L.,Sofou Stavroula^ORCID

Funder

W. W. Smith Charitable Trust

Allegheny Health Network-Johns Hopkins Cancer Research Fund

Elsa U. Pardee Foundation

Publisher

Springer Science and Business Media LLC

Link

https://link.springer.com/content/pdf/10.1007/s00259-024-06710-0.pdf

Reference29 articles.

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2. Karlsson J. Abstract ND07: HER2-TTC: a targeted thorium conjugate to treat HER2 expressing cancers with potent alpha radiation. Cancer Research. 2021;81:ND07-ND. https://doi.org/10.1158/1538-7445.Am2021-nd07.

3. Yard BD, Gopal P, Bannik K, Siemeister G, Hagemann UB, Abazeed ME. Cellular and genetic determinants of the sensitivity of cancer to α-particle irradiation. Can Res. 2019;79:5640–51. https://doi.org/10.1158/0008-5472.can-19-0859.

4. Howe A, Bhatavdekar O, Salerno D, Josefsson A, Pacheco-Torres J, Bhujwalla ZM, et al. Combination of carriers, with complementary intratumoral microdistributions of delivered α-particles, may realize the promise for actinium-225 in large solid tumors. J Nucl Med. 2022;63:1223–30. https://doi.org/10.2967/jnumed.121.262992.

5. Katugampola S, Wang J, Prasad A, Sofou S, Howell RW. Predicting response of micrometastases with MIRDcell V3: proof of principle with 225Ac-DOTA encapsulating liposomes that produce different activity distributions in tumor spheroids. Eur J Nucl Med Mol Imaging. 2022;49:3989–99. https://doi.org/10.1007/s00259-022-05878-7.

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