Clinical impact of Prostate-Specific Membrane Antigen Positron Emission Tomography (PET) on intensification or deintensification of advanced renal cell carcinoma management

Author:

Pathmanathan Shivanshan,Tariq Arsalan,Pearce Adam,Rhee Handoo,Kyle Samuel,Raveenthiran Sheliyan,Wong David,McBean Rhiannon,Marsh Phillip,Goodman Steven,Dhiantravan Nattakorn,Esler Rachel,Dunglison Nigel,Navaratnam Anojan,Yaxley John,Thomas Paul,Pattison David A.,Goh Jeffrey C.,Gan Chun Loo,Roberts Matthew J.ORCID

Abstract

Abstract Purpose There is an emerging role of the use of Prostate-Specific Membrane Antigen (PSMA) Positron Emission Tomography (PET) in renal cell carcinoma. Herein, we report our experience in use of PSMA PET in recurrent or metastatic renal cell carcinoma (RCC). Methods A retrospective analysis of all patients who underwent PSMA PET for suspected recurrent or de-novo metastatic RCC between 2015 and 2020 at three institutions was performed. The primary outcome was change in management (intensification or de-intensification) following PSMA PET scan. Secondary outcomes included histopathological correlation of PSMA avid sites, comparison of sites of disease on PSMA PET to diagnostic CT and time to systemic treatment. Results

Funder

The University of Queensland

Publisher

Springer Science and Business Media LLC

Subject

Radiology, Nuclear Medicine and imaging,General Medicine,Radiology, Nuclear Medicine and imaging,General Medicine

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