Increased Cellular Presence After Sciatic Neurectomy Improves the Bone Mechano-adaptive Response in Aged Mice

Author:

Piet Judith,Hu Dorothy,Meslier Quentin,Baron Roland,Shefelbine Sandra J.ORCID

Funder

Northeastern University

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology,Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

Reference63 articles.

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2. Willie BM, Birkhold AI, Razi H, Thiele T, Aido M, Kruck B et al (2013) Diminished response to in vivo mechanical loading in trabecular and not cortical bone in adulthood of female C57Bl/6 mice coincides with a reduction in deformation to load. Bone 55:335–346. https://doi.org/10.1016/j.bone.2013.04.023

3. Yang H, Butz KD, Duffy D, Niebur GL, Nauman EA, Main RP (2014) Characterization of cancellous and cortical bone strain in the in vivo mouse tibial loading model using microCT-based finite element analysis. Bone 66:131–139. https://doi.org/10.1016/j.bone.2014.05.019

4. Saxon LK, Jackson BF, Sugiyama T, Lanyon LE, Price JS (2011) Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it. Bone 49:184–193. https://doi.org/10.1016/j.bone.2011.03.683

5. De Souza RL, Matsuura M, Eckstein F, Rawlinson SCF, Lanyon LE, Pitsillides AA (2005) Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element. Bone 37:810–818. https://doi.org/10.1016/j.bone.2005.07.022

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