Use of Mortality as an Endpoint in Noninferiority Trials May Lead to Ethically Problematic Conclusions
Author:
Publisher
Springer Science and Business Media LLC
Subject
Internal Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11606-018-4813-z.pdf
Reference41 articles.
1. Soonawala D, Middelburg RA, Egger M, Vandenbroucke JP, Dekkers OM. Efficacy of experimental treatments compared with standard treatments in non-inferiority trials: a meta-analysis of randomized controlled trials. Int J Epidemiol. 2010;39(6):1567–1581.
2. Le Henanff A, Giraudeau B, Baron G, Ravaud P. Quality of reporting of noninferiority and equivalence randomized trials. JAMA. 2006;295(10):1147–1151.
3. Flacco ME, Manzoli L, Boccia S, et al. Head-to-head randomized trials are mostly industry sponsored and almost always favor the industry sponsor. J Clin Epidemiol. 2015;68(7):811–820.
4. Garattini S, Bertele’ V. Non-inferiority trials are unethical because they disregard patients' interests. Lancet. 2007;370(9602):1875–1877.
5. Lesaffre E. Superiority, equivalence, and non-inferiority trials. Bull NYU Hosp Jt Dis. 2008;66(2):150–154.
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