Differential effects of the bicyclic imidazoles on cytokine biosynthesis in human monocytes and endothelial cells

Author:

Lee J. C.,Laydon J. T.,White J. R.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Toxicology,Pharmacology,Immunology

Reference7 articles.

1. P. E. Bender and J. C. Lee,Pharmacological modulation of Interleukin-1. In: Ann. Rep. Med. Chem. Ed. J. A. Bristol25. 185–193 (1990).

2. J. C. Lee, A. M. Badger, D. E. Griswold, D. Dunnington, A. Truneh, B. Votta, J. R. White, P. R. Young and P. E. BenderBicyclic imidazoles as a novel class of cytokine biosynthesis inhibitors. Ann. New York Acad. Sci. (in press).

3. J. C. Lee, B. Votta, B. J. Dalton, D. E. Griswold, P. E. Bender and N. Hanna,Inhibition of human monocyte IL-1 production by SK&F 86002. Int. J. Immunother.6, 1–12 (1990).

4. P. R. Young, P. McDonnell, D. Dunnington, A. Hang, J. Laydon and J. C. Lee,Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level. Agents and Actions39, C67-C69 (1993).

5. A. M. Badger, D. L. Olivera, J. E. Talmadge and N. Hanna,Protective effect of SK&F 86002, a novel dual inhibitor of arachidonic acid metabolism, in murine models of endotoxic shock: Inhibition of tumor necrosis factor as a possible mechanism of action. Circ. Shock.27, 51–61 (1989).

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