The relationship between depression and cardiovascular disorders

Author:

Malhotra Shishuka,Tesar George E.,Franco Kathleen

Publisher

Springer Science and Business Media LLC

Subject

Psychiatry and Mental health

Reference19 articles.

1. Glassman AH, Shapiro PA: Depression and the course of coronary artery disease. Am J Psychiatry 1998, 155:4–11. A comprehensive yet concise literature-review that critically assesses scientific studies of the long-recognized link between depression and death from cardiovascular disease. The focus is on community and epidemiologic surveys and clinical studies that have contributed to the recognition of depression as an independent risk factor for cardiovascular death. Less attention is devoted to pathophysiologic mechanisms.

2. Frasure-Smith, Lesperance F, Juneau M, et al.: Gender, depression, and one-year prognosis after myocardial infarction. Psychosom Med 1999, 61:26–37. A further analysis of data from the original 1993 study focusing on the impact of gender on prognosis and outcome in depressed patients following MI.

3. Strik JMH, Honig A, Lousberg R, et al.: A double-blind placebocontrolled study of efficacy and safety of fluoxetine in patients with major depression following a first myocardial infarction [abstract]. Presented at the Annual Meeting of the American Psychiatry Association. Washington DC, May 15–20, 1999. Aside from the SADHART study this is the only prospective, randomized trial of treatment for depression in post-MI patients. Fluoxetine was no better than placebo for depression, but was associated with fewer re-admissions for post-MI cardiac complications and resulted in a significant reduction of hostility.

4. Shaprio PA, Lesperance F, Frasure-Smith N, et al.: An open-label preliminary trial of sertraline for treatment of major depression after acute myocardial infarction (the SADHART Trial). Am Heart J 1999, 137:1100–1106. This reports the pilot phase of the large randomized, controlled SADHART study. Twenty-six patients were treated with sertraline at a mean dose of 79.8 mg/d with good results. Bleeding time was increased in 12 of 18 patients (67%) studied.

5. Rozanski A, Blumenthal JA, Kaplan J: Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. 1999, 99:2192-2217. An encyclopedic review by well-known psychologists of the relationship between psychosocial factors and heart disease.

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