Treatment Advances in Chronic Non-Bacterial Osteomyelitis and Other Autoinflammatory Bone Conditions

Author:

Zhao Yongdong,Laxer Ronald M.,Ferguson Polly J.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology

Reference68 articles.

1. • Wipff J, Costantino F, Lemelle I, Pajot C, Duquesne A, Lorrot M, et al. A large national cohort of French patients with chronic recurrent multifocal osteitis. Arthritis Rheumatol. 2015;67:1128–37. The largest CNO cohort reported three homogeneous phenotypes using cluster analysis. Majority of patients with unifocal presentation developed multifocal lesions during long-term follow-up.

2. Jansson A, Renner ED, Ramser J, Mayer A, Haban M, Meindl A, et al. Classification of non-bacterial osteitis: retrospective study of clinical, immunological and genetic aspects in 89 patients. Rheumatology (Oxford). 2007;46:154–60.

3. • Voit AM, Arnoldi AP, Douis H, Bleisteiner F, Jansson MK, Reiser MF, et al. Whole-body magnetic resonance imaging in chronic recurrent multifocal osteomyelitis: clinical longterm assessment may underestimate activity. J Rheumatol. 2015;42:1455–62. The first study using whole-body MRI in adult patients who had childhood disease onset provided evidence of persistent inflammation of CRMO into adulthood regardless of clinical disease status. It highlights the importance of continuing monitoring of disease with imaging and appropriate treatment for CRMO patients during their adulthood. It also demonstrated that many patients have ongoing pain in the absence of inflammation on MRI.

4. Hofmann SR, Morbach H, Schwarz T, Rösen-Wolff A, Girschick HJ, Hedrich CM. Attenuated TLR4/MAPK signaling in monocytes from patients with CRMO results in impaired IL-10 expression. Clin Immunol Elsevier Inc.; 2012;145:69–76.

5. • Hofmann SR, Kubasch AS, Range U, Laass MW, Morbach H, Girschick HJ, et al. Serum biomarkers for the diagnosis and monitoring of chronic recurrent multifocal osteomyelitis (CRMO). Rheumatol Int Springer Berlin Heidelberg; 2016;36:769–79. This study explored the potential of serum biomarkers to distinguish between patients with CRMO or Crohn’s disease and healthy individuals.

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