Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning-Reference-Cited by-同舟云学术

Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning

Published:2023-07-05 Issue:4 Volume:79 Page:731-743
ISSN:1138-7548
Container-title:Journal of Physiology and Biochemistry
language:en
Short-container-title:J Physiol Biochem

Author:

Peixoto Álbert S.^ORCID,Moreno Mayara F.^ORCID,Castro Érique^ORCID,Perandini Luiz A.^ORCID,Belchior Thiago^ORCID,Oliveira Tiago E.^ORCID,Vieira Thayna S.^ORCID,Gilio Gustavo R.^ORCID,Tomazelli Caroline A.^ORCID,Leonardi Bianca F.^ORCID,Ortiz-Silva Milene^ORCID,Silva Junior Luciano P.^ORCID,Moretti Eduardo H.^ORCID,Steiner Alexandre A.^ORCID,Festuccia William T.^ORCID

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Springer Science and Business Media LLC

Subject

General Medicine,Biochemistry,Physiology

Link

https://link.springer.com/content/pdf/10.1007/s13105-023-00970-4.pdf

Reference59 articles.

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2. Badman MK, Pissios P, Kennedy AR et al (2007) Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab 5:426–437. https://doi.org/10.1016/J.CMET.2007.05.002

3. Bae JJ, Rho JW, Lee TJ et al (2007) Loss of heterozygosity on chromosome 10q23 and mutation of the phosphatase and tensin homolog deleted from chromosome 10 tumor suppressor gene in Korean hepatocellular carcinoma patients. Oncol Rep 18:1007–1013. https://doi.org/10.3892/or.18.4.1007

4. Becker AS, Zellweger C, Bacanovic S et al (2020) Brown fat does not cause cachexia in cancer patients: a large retrospective longitudinal FDG-PET/CT cohort study. PLoS One 15(10):e0239990. https://doi.org/10.1371/journal.pone.0239990

5. Berthou F, Sobolewski C, Abegg D et al (2022) Hepatic PTEN signaling regulates systemic metabolic homeostasis through hepatokines-mediated liver-to-peripheral organs crosstalk. Int J Mol Sci 23(7):3959. https://doi.org/10.3390/IJMS23073959