New Pharmacological Approaches to Treating Non-Motor Symptoms of Parkinson’s Disease

Author:

Kelberman Michael A.,Vazey Elena M.

Funder

National Institute of Mental Health

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology,Genetics,Biochemistry

Reference100 articles.

1. de Lau LML, Breteler MMB. Epidemiology of Parkinson’s disease. Lancet Neurol. 2006;5:525–35.

2. Kadastik-Eerme L, Muldmaa M, Lilles S, Rosenthal M, Taba N, Taba P. Nonmotor features in Parkinson’s disease: what are the most important associated factors? Parkinsons Dis. 2016;2016:4370674. There is a growing concern about negative health related impacts of non-motor symptoms for PD patients. This study showed almost universal prevalence of non-motor symptoms in PD as well as evidence that levodopa treatment is associated with a higher burden of non-motor symptoms.

3. Erro R, Roberto E, Marina P, et al. Non-motor symptoms in early Parkinson’s disease: a 2-year follow-up study on previously untreated patients. J Neurol Neurosurg Psychiatry. 2012;84:14–7.

4. Duncan GW, Khoo TK, Yarnall AJ, O’Brien JT, Coleman SY, Brooks DJ, et al. Health-related quality of life in early Parkinson’s disease: the impact of nonmotor symptoms. Mov Disord. 2014;29:195–202.

5. Shulman LM, Taback RL, Rabinstein AA, Weiner WJ. Non-recognition of depression and other non-motor symptoms in Parkinson’s disease. Parkinsonism Relat Disord. 2002;8:193–7.

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