The Use of Rat Heterotopic Heart Transplantation Models to Characterize the Immunosuppressive Activities of Leflunomide

Author:

Chong A. S.-F.,Shen J-K.,Yin D-P.,Williams J. W.

Publisher

Springer Berlin Heidelberg

Reference58 articles.

1. Bartlett RR, Dimitrijevic M, Mattar T, Zielinski T, Germann T, Rüde E, et al (1991) Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection. Agents Actions 32:10–21

2. Silva H, Morris R (1997) Leflunomide and malonitriloamides. Exp Opin Invest Drugs 6:51–64

3. Seimasko K, Chong A, Jack H-M, Xu X, Gong H, Williams J, et al (1998) The immunosuppressive agent, leflunomide, inhibits immunoglobulin production by two independent mechansims. J Immunol (in press)zzz

4. Elder R, Xu X, Williams J, Gong H, Finnegan A, Chong A-F (1997) The immunosuppressive drug metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms. J Immunol 159:22–27

5. Xu X, Williams J, Bremer E, Finnegan A, Chong A (1995) Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide. J Biol Chem 270:123898–12403

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