A Gas Chromatographic Method for the Determination of Ethotoin (3-Ethyl-5-Phenylhydantoin) in Human Plasma-Reference-Cited by-同舟云学术

A Gas Chromatographic Method for the Determination of Ethotoin (3-Ethyl-5-Phenylhydantoin) in Human Plasma

Published:1975 Issue: Volume: Page:115-123
ISSN:
Container-title:Clinical Pharmacology of Anti-Epileptic Drugs
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Author:

Yonekawa W.,Kupferberg H. J.,Cantor F.

Publisher

Springer Berlin Heidelberg

Link

http://link.springer.com/content/pdf/10.1007/978-3-642-85921-2_10.pdf

Reference12 articles.

1. Carter, C. H., Maley, M. C.: Clinical evaluation of Peganone®, a new anticonvulsant. Amer. J. Med. Sci. 234, 74 (1957).

2. Chang, T., Glazko, A. J.: Quantitative assay of 5,5-diphenylhydantoin (Dilantin®) and 5-(p - hydroxyphenyl)-5-phenylhydantoin by gas-liquid chromatography. J. Lab. clin. Med. 75, 145 (1970).

3. Dudley, K. H., Bius, D. L., Butler, T. C.: Metabolic fates of 3-ethyl-5-phenylhydantoin (ethotoin, Peganone®), 3-methyl-5-phenylhydantoin and 5-phenylhydantoin. J. Pharmacol, exp. ther. 175, 27 (1970).

4. Gruber, C. M., jr., Brock, J. T., Dyken, M.: Comparison of the effectiveness of phenobarbital, mephobarbital, primidone, diphenylhydantoin, ethotoin, metharbital, and methylphenylethylhydantoin in motor seizures. Clin. Pharmacol. Ther. 3, 23 (1962).

5. Hammer, R. H., Wilder, B. J., Streiff, R. R., Mayersdorf, A.: Flash methylation and gasliquid chromatography of diphenylhydantoin and 5-(p-hydroxyphenyl)-5-phenylhydantoin. J. pharm. Sci. 60, 327 (1971).

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1. Enantioselective pharmacokinetics of ethotoin in humans following single oral doses of the racemate;Chirality;1992

2. Neoplasms;Neurological Clinical Pharmacology;1980

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