Understanding Molecular Mechanisms of Toxicity and Carcinogenicity Using Gene Knockout and Transgenic Mouse Models

Author:

Elizondo G.,Gonzalez F. J.

Publisher

Springer Berlin Heidelberg

Reference111 articles.

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2. Andreola F, Fernandez-Salguero PM, Chiantore MV, Petkovich MP, Gonzalez FJ, De Luca LM (1997) Aryl hydrocarbon receptor knockout mice (AHR-/-) exhibit liver retinoid accumulation and reduced retinoic acid metabolism. Cancer Res 57:2835–2838

3. Anwar A, Dehn D, Siegel D, Kepa JK, Tang LJ, Pietenpol JA, Ross D (2003) Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQO1) with the tumor suppressor protein p53 in cells and cell-free systems. J Biol Chem 278:10368–10373

4. Aoyama T, Korzekwa K, Matsunaga T, Nagata K, Gillette J, Gelboin HV, Gonzalez FJ (1990) cDNA-directed expression of rat P450s IIA1 and IIA2. Catalytic activities toward steroids and xenobiotics and comparison with the enzymes purified from liver. Drug Metab Dispos 18:378–382

5. Baes M, Gulick T, Choi HS, Martinoli MG, Simha D, Moore DD (1994) A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Mol Cell Biol 14:1544–1551

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