Miscellaneous Applications of Iptycenes and Their Derivatives

Author:

Chen Chuan-Feng,Ma Ying-Xian

Publisher

Springer Berlin Heidelberg

Reference28 articles.

1. Perchellet EM, Magill MJ, Huang XD, Brantis CE, Hua DH, Perchellet JP (1999) Triptycenes: a novel synthetic class of bifunctional anticancer drugs that inhibit nucleoside transport, induce DNA cleavage and decrease the viability of leukemic cells in the nanomolar range in vitro. Anticancer Drugs 10(8):749–766

2. Wang Y, Perchellet EM, Tamura M, Hua DH, Perchellet JP (2002) Induction of poly(ADP-ribose) polymerase-1 cleavage by antitumor triptycene bisquinones in wild-type and daunorubicin-resistant HL-60 cell lines. Cancer Lett 188(1–2):73–83

3. Wang BN, Perchellet EM, Wang Y, Tamura M, Hua DH, Perchellet JPH (2003) Antitumor triptycene bisquinones: a novel synthetic class of dual inhibitors of DNA topoisomerase I and II activities. Anticancer Drugs 14(7):503–514

4. Wang BN, Wu MF, Perchellet EM, McIlvain CJ, Sperfslage BJ, Huang XD, Tamura M, Stephany HA, Hua DH, Perchellet JP (2001) A synthetic triptycene bisquinone, which blocks nucleoside transport and induces DNA fragmentation, retains its cytotoxic efficacy in daunorubicin-resistant HL-60 cell lines. Int J Oncol 19(6):1169–1178

5. Perchellet EM, Sperfslage BI, Wang Y, Huang XD, Tamura M, Hua DH, Perchellet JP (2002) Among substituted 9,10-dihydro-9,10-[1,2] benzenoanthracene-1,4,5,8-tetraones, the lead antitumor triptycene bisquinone TT24 blocks nucleoside transport, induces apoptotic DNA fragmentation and decreases the viability of L1210 leukemic cells in the nanomolar range of daunorubicin in vitro. Anticancer Drugs 13(6):567–581

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