May Prolonged High Doses of Nitrates Cause Tolerance? Preliminary Results on the Response to an Additional Dose by Infusion

Author:

Distante A.,L’Abbate A.,Palombo C.,Michelassi C.,Rovai D.,Morales M. A.,Sabino F.,Moscarelli E.,Lombardi M.,Maseri A.

Publisher

Springer Berlin Heidelberg

Reference8 articles.

1. Danahy DT, Aronow WS (1977) Hemodynamic and antianginal effects of high dose oral isosorbide dinitrate after chronic use. Circulation 56: 205–217

2. Distante A, Maseri A, Severi S, Biagini A, Chierchia S (1979) Management of vasospastic angina at rest with continuous infusion of isosorbide dinitrate. Am J Cardiol 44: 533–539

3. Down WH, Chasseaud LF (1976) The percutaneous absorption of 14C-isosorbide dinitrate in rats, rabbits and man. In: Rudolph W, Siegenthaler W (eds) Nitrate: Wirkung auf Herz und Kreislauf. Nitrat-Symposion Stockholm ( 1975 ). Urban & Schwarzenberg, Munich, pp 14–17

4. Mason DT, Braunwald E (1965) The effects of nitroglycerin and amyl nitrite on arteriolar and venous tone in the human forearm. Circulation 32: 755–766

5. Needleman P, Johnson EM (1973) Mechanism of tolerance development to organic nitrates. J Pharmacol Exp Ther 184: 709

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1. Nitrates;Developments in Cardiovascular Medicine;1987

2. Organic Nitrates;Handbook of Experimental Pharmacology;1985

3. Clinical Relevance of Nitrate Tolerance;Mononitrates;1985

4. Tolerance and Rebound Phenomena in Nitrate Therapy;Mononitrates;1985

5. Molsidomine;Cardiovascular Drug Reviews;1984-03

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