Intratumorale Thymidylatsynthasespiegel können ein längeres tumorfreies Überleben unter adjuvanter 5-Fluorouraciltherapie bei Patienten mit kolorektalen Karzinomen vorhersagen

Author:

Kornmann M.,Schwabe W.,Sträter J.,Häusler P.,Beger H. G.,Behnke D.,Link K. H.

Publisher

Springer Berlin Heidelberg

Reference5 articles.

1. Kornmann M, Danenberg KD, Arber N, Beger HG, Danenberg PV, Korc M (1999) Inhibition of cyclin D1 expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes. Cancer Res 59: 3505–3511

2. Link KH, Staib L, Bernhart H, Kreuser ED, Suhr P, Röttinger E, Beger HG (1997) Acceptannce and toxicity of postoperative adjuvant therapy in colon and rectal cancers. Onkologie 20: 235–238

3. Masuda N, Ohnishi T, Kawamoto S, Monden M, Okubo K (1999) Analysis of chemical modification of RNA from formalin-fixed samples and optimization of molecular biology applications for such samples. Nucl Acids Res 27: 4436–4443

4. Salonga D, Danenberg KD, Johnson M, Metzger R, Groshen S, Tsao-Wei DD, Lenz HJ, Leichman CG, Leichman L, Diasio RB, Danenberg PV (2000) Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin Cancer Res 6: 1322–1327

5. Van Triest B, Pinedo HM, Giaccone G, Peters GJ (2000) Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors. Ann Oncol 11: 385–391

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