Liver Cytochrome P450 Metabolism of Endogenous Steroid Hormones, Bile Acids, and Fatty Acids

Author:

Zimniak P.,Waxman D. J.

Publisher

Springer Berlin Heidelberg

Reference94 articles.

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2. Aoyama T, Korzekwa K, Nagata K, Gillette J, Gelboin HV, Gonzales FJ (1989a) cDNA-directed expression of rat testosterone 7α-hydroxylase using the modified vaccinia virus, T7-RNA-polymerase system and evidence for 6α-hydroxylation and A6-testosterone formation. Eur J Biochem 181: 331–336

3. Aoyama T, Korzekwa K, Nagata K, Adesnik M, Reiss A, Lapenson DP, Gillette J, Gelboin HV, Waxman DJ, Gonzalez FJ (1989b) Sequence requirements for cytochrome P-450IIB1 catalytic activity. Alteration of the stereospecificity and regioselectivity of steroid hydroxylation by a simultaneous change of two hydrophobic amino acid residues to phenylalanine. J Biol Chem 264: 21327–21333

4. Aoyama T, Yamano S, Waxman DJ, Lapenson DP, Meyer UA, Fischer V, Tyndale R, Inaba T, Kalow W, Gelboin HV, Gonzalez FJ (1989c) Cytochrome P-450 hPCN3, a novel cytochrome P-450 III A gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCNl and hPCN3 for the metabolism of steroid hormones and cyclosporine. J Biol Chem 264: 10388–10395

5. Aoyama T, Hardwick JP, Imaoka S, Funae Y, Gelboin HV, Gonzalez FJ (1990) Clofibrate-inducible rat hepatic P450s IVA1 and IVA3 catalyze the ω- and (ω-l)-hydroxylation of fatty acids and the ω-hydroxylation of prostaglandins El and F2α. J Lipid Res 31: 1477–1482

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