Increased prostate-specific membrane antigen expression in LNCaP cells following treatment with bispecific antisense oligonucleotides directed against bcl-2 and EGFR-Reference-Cited by-同舟云学术

Increased prostate-specific membrane antigen expression in LNCaP cells following treatment with bispecific antisense oligonucleotides directed against bcl-2 and EGFR

Published:2009-11-24 Issue:4 Volume:27 Page:1212-1218
ISSN:1357-0560
Container-title:Medical Oncology
language:en
Short-container-title:Med Oncol

Author:

Rubenstein Marvin,Hollowell Courtney M. P.,Guinan Patrick

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,Hematology,General Medicine

Link

http://link.springer.com/content/pdf/10.1007/s12032-009-9361-2.pdf

Reference18 articles.

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2. Felsenfeld G, Miles HT. Formation of a three-stranded polynucleotide molecule. J Am Chem Soc. 1957;79:2023–4.

3. Durland RH, Kessler DJ, Hogan M. Antiparallel triplex formation at physiological pH. In: Wickstrom E, editor. Prospects for antisense nucleic acid therapy of cancer and AIDS. New York: Wiley-Liss; 1991. p. 219–26.

4. Rubenstein M, Tsui P, Guinan P. Bispecific antisense oligonucleotides with multiple binding sites for the treatment of prostate tumors and their applicability to combination therapy. Methods Find Clin Pharmacol. 2006;28:515–8.

5. Rubenstein M, Tsui P, Guinan P. Combination chemotherapy employing bispecific antisense oligonucleotides having binding sites directed against an autocrine regulated growth pathway and bcl-2 for the treatment of prostate cancer. Med Oncol. 2007;24:372–8.

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1. Oligonucleotide suppression of bcl-2 in LNCaP cells is compensated by increased androgen sensitivity, p53 and oncogene activity, and suppressed caspase-3;Medical Oncology;2013-05-16

2. Compensatory and non-compensatory effects on protein expression following BCL-2 suppression by antisense oligonucleotides;Medical Oncology;2011-10-30

3. In LNCaP cells enhanced expression of both androgen receptor and costimulatory protein p300 compensate for antisense oligonucleotide suppression of bcl-2;Therapeutic Advances in Urology;2011-10-27