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Steroidal saponin SSPH I induces ferroptosis in HepG2 cells via regulating iron metabolism

  • Published:2023-03-28 Issue:5 Volume:40 Page:
  • ISSN:1559-131X
  • Container-title:Medical Oncology
  • language:en
  • Short-container-title:Med Oncol

Author:

Huang Dan,Dong Xin,Li Jianzhe,Chen Yudan,Zhou Ying,Chen Qingjie,Sun YuewenORCID

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangxi Province

Qihuang Project Team of Guangxi University of Chinese Medicine

Self-raised project of the Department of Agriculture and Rural Affairs of Guangxi

Self-raised project of the Administration of Traditional Chinese Medicine of Guangxi

Doctor funding of Ruikang Hospital affiliated to Guangxi University of Chinese Medicine

Young talents in Gui Pai Xing lin of Guangxi University of Chinese Medicine

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,Hematology,General Medicine

Reference40 articles.

1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. https://doi.org/10.3322/caac.21492 (Epub 2018/09/13; PubMed PMID: 30207593).

2. Samant H, Amiri HS, Zibari GB. Addressing the worldwide hepatocellular carcinoma: epidemiology, prevention and management. J Gastrointest Oncol. 2021;12(Suppl 2):S361–S73. https://doi.org/10.21037/jgo.2020.02.08 (Epub 2021/08/24; PubMed PMID: 34422400; PubMed Central PMCID: PMCPMC8343080).

3. Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A, Roberts LR. A global view of hepatocellular carcinoma: trends, risk, prevention and management. Nat Rev Gastroenterol Hepatol. 2019;16(10):589–604. https://doi.org/10.1038/s41575-019-0186-y (Epub 2019/08/24; PubMed PMID: 31439937; PubMed Central PMCID: PMCPMC6813818).

4. Luo L, Yao X, Xiang J, Huang F, Luo H. Identification of ferroptosis-related genes for overall survival prediction in hepatocellular carcinoma. Sci Rep. 2022;12(1):10007. https://doi.org/10.1038/s41598-022-14554-7 (Epub 2022/06/16; PubMed PMID: 35705729; PubMed Central PMCID: PMCPMC9200861).

5. Werth EG, Rajbhandari P, Stockwell BR, Brown LM. Time course of changes in sorafenib-treated hepatocellular carcinoma cells suggests involvement of phospho-regulated signaling in ferroptosis induction. Proteomics. 2020;20(10):e2000006. https://doi.org/10.1002/pmic.202000006 (Epub 2020/04/27; PubMed PMID: 32336023; PubMed Central PMCID: PMCPMC7305944).

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