Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin-Reference-Cited by-同舟云学术

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Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin

Published:2006-11-17 Issue:2 Volume:52 Page:117-122
ISSN:1434-5161
Container-title:Journal of Human Genetics
language:en
Short-container-title:J Hum Genet

Author:

Shikata Eriko,Yamamoto Rei,Takane Hiroshi,Shigemasa Chiaki,Ikeda Tadasu,Otsubo Kenji,Ieiri Ichiro

Publisher

Springer Science and Business Media LLC

Subject

Genetics (clinical),Genetics

Link

http://www.nature.com/articles/jhg200716.pdf

Reference17 articles.

1. DeFronzo RA, Goodman AM (1995) Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. N Engl J Med 333:541–549

2. Hundal RS, Krssak M, Dufour S, Laurent D, Lebon V, Chandramouli V, Inzucchi SE, Schumann WC, Petersen KF, Landau BR, Shulman GI (2000) Mechanism by which metformin reduces glucose production in type 2 diabetes. Diabetes 49:2063–2069

3. Itoda M, Saito Y, Maekawa K, Hichiya H, Komamura K, Kamakura S, Kitakaze M, Tomoike H, Ueno K, Ozawa S, Sawada J (2004) Seven novel single nucleotide polymorphisms in the human SLC22A1 gene encoding organic cation transporter 1(OCT1). Drug Metab Pharmacokinet 19:308–312

4. Jonker JW, Schinkel AH (2004) Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1–3). J Pharmacol Exp Ther 308:2–9

5. Kerb R, Brinkmann U, Chatskaia N, Gorbunov D, Gorboulev V, Mornhinweg E, Keil A, Eichelbaum M, Koepsell H (2002) Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences. Pharmacogenetics 12:591–595

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