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5. • Zhang MY, Churpek JE, Keel SB, Walsh T, Lee MK, Loeb KR, et al. Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy. Nat Genet. 2015;47(2):180–5. This study documents germline missense mutations in ETV6 segregating with thrombocytopenia and hematologic malignancy in 3 unrelated families. Functional studies support the role of ETV6 as a germline susceptibility to autosomal dominant thrombocytopenia and risk for hematologic malignancy by decreased transcriptional repression and impaired hematopoiesis.