Regulation of Neuronal Gene Expression by Local Axonal Translation
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Medicine
Link
http://link.springer.com/content/pdf/10.1007/s40142-016-0085-2.pdf
Reference90 articles.
1. • Kim S, Martin KC. Neuron-wide RNA transport combines with netrin-mediated local translation to spatially regulate the synaptic proteome. eLife. 2015;4:e04158. By investigating how presynaptic translation can be limited specifically to activated synapses despite broad distribution of presynaptic RNAs, this study identified that postsynaptic activity induces calcium-dependent release of netrin. This netrin binds to its presynaptic receptor to induce local translation only at activated synapses.
2. Andreassi C, Zimmermann C, Mitter R, Fusco S, De Vita S, Devita S, et al. An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons. Nat Neurosci. 2010;13(3):291–301.
3. •• Baleriola J, Walker CA, Jean YY, Crary JF, Troy CM, Nagy PL, et al. Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions. Cell. 2014;158(5):1159–72. Alzheimer’s pathology appears to spread over long distances between brain regions that are connected with each other. This paper reveals that axon exposure to pathogenic Aβ oligomers induces the axonal transport and subsequent axonal translation of transcripts that can induce neurodegeneration.
4. Merianda TT, Coleman J, Kim HH, Kumar Sahoo P, Gomes C, Brito-Vargas P, et al. Axonal amphoterin mRNA is regulated by translational control and enhances axon outgrowth. J Neurosci. 2015;35(14):5693–706.
5. Kislauskis EH, Zhu X, Singer RH. Sequences responsible for intracellular localization of beta-actin messenger RNA also affect cell phenotype. J Cell Biol. 1994;127(2):441–51.
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