Pharmacokinetics-pharmacodynamics of sertraline as an antifungal in HIV-infected Ugandans with cryptococcal meningitis

Author:

Alhadab Ali A.ORCID, ,Rhein Joshua,Tugume Lillian,Musubire Abdu,Williams Darlisha A.,Abassi Mahsa,Nicol Melanie R.,Meya David B.,Boulware David R.,Brundage Richard C.

Funder

National Center for Advancing Translational Sciences of the National Institute of Health Award

National Institute of Neurological Disorders and Stroke

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology

Reference52 articles.

1. Rajasingham R, Smith RM, Park BJ, Jarvis JN, Govender NP, Chiller TM, Denning DW, Loyse A, Boulware DR (2017) Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis. Lancet Infect Dis 17:873–881. https://doi.org/10.1016/S1473-3099(17)30243-8Elsevier

2. Park BJ, Wannemuehler KA, Marston BJ, Govender N, Pappas PG, Chiller TM (2009) Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. Aids 23:525–530. https://doi.org/10.1097/QAD.0b013e328322ffac

3. Rhein J, Morawski BM, Hullsiek KH, Nabeta HW, Kiggundu R, Tugume L, Musubire A, Akampurira A, Smith KD, Alhadab A, Williams DA, Abassi M, Bahr NC, Velamakanni SS, Fisher J, Nielsen K, Meya DB, Boulware DR, Ndyetukira JF, Ahimbisibwe C, Kugonza F, Sadiq A, Kandole TK, Luggya T, Kaboggoza J, Laker E, Butler EK, Dyal J, Neborak JM, King AM, Fujita AW, Yueh N, Namudde A, Halupnick R, Jawed B, Vedula P, Peterson M, Bohjanen PR, Kambugu A (2016) Efficacy of adjunctive sertraline for the treatment of HIV-associated cryptococcal meningitis: an open-label dose-ranging study. Lancet Infect Dis 16:809–818. https://doi.org/10.1016/S1473-3099(16)00074-8

4. Boulware DR, Meya DB, Muzoora C, Rolfes MA, Huppler Hullsiek K, Musubire A, Taseera K, Nabeta HW, Schutz C, Williams DA, Rajasingham R, Rhein J, Thienemann F, Lo MW, Nielsen K, Bergemann TL, Kambugu A, Manabe YC, Janoff EN, Bohjanen PR, Meintjes G (2014) Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis. N Engl J Med 370:2487–2498. https://doi.org/10.1056/NEJMoa1312884

5. Jarvis JN, Bicanic T, Loyse A, Namarika D, Jackson A, Nussbaum JC, Longley N, Muzoora C, Phulusa J, Taseera K, Kanyembe C, Wilson D, Hosseinipour MC, Brouwer AE, Limmathurotsakul D, White N, Van Der Horst C, Wood R, Meintjes G, Bradley J, Jaffar S, Harrison T (2014) Determinants of mortality in a combined cohort of 501 patients with HIV-associated cryptococcal meningitis: implications for improving outcomes. Clin Infect Dis 58:736–745. https://doi.org/10.1093/cid/cit794

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