Dose selection using a semi-mechanistic integrated glucose-insulin-glucagon model: designing phase 2 trials for a novel oral glucokinase activator
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology
Link
http://link.springer.com/content/pdf/10.1007/s10928-012-9286-9.pdf
Reference42 articles.
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2. Wilson JE (2003) Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function. J Exp Biol 206(Pt 12):2049–2057
3. Iynedjian PB (2009) Molecular physiology of mammalian glucokinase. Cell Mol Life Sci 66(1):27–42
4. Kevin R, Guertin JG (2006) Small molecule glucokinase activators as glucose lowering agents: a new paradigm for diabetes therapy. Curr Med Chem 13(15):1839–1843
5. Grimsby J, Berthel SJ, Sarabu R (2008) Glucokinase activators for the potential treatment of type 2 diabetes. Curr Top Med Chem 8(17):1524–1532
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