A next generation mathematical model for the in vitro to clinical translation of T-cell engagers
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology
Link
https://link.springer.com/content/pdf/10.1007/s10928-023-09846-y.pdf
Reference33 articles.
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3. Saber H, Del Valle P, Ricks TK, Leighton JK (2017) An FDA oncology analysis of CD3 bispecific constructs and first-in-human dose selection. Regul Toxicol Pharmacol 90:144–152
4. Sun LL, Ellerman D, Mathieu M, Hristopoulos M, Chen X, Li Y et al (2015) Anti-CD20/CD3 T cell–dependent bispecific antibody for the treatment of B cell malignancies. Sci Transl Med. 7:287
5. Betts A, Haddish-Berhane N, Shah DK, van der Graaf PH, Barletta F, King L et al (2019) A translational quantitative systems pharmacology model for CD3 bispecific molecules: application to quantify T cell-mediated tumor cell killing by P-cadherin LP DART®. AAPS J 21:66
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