Abstract
AbstractThe lack of efficient drug delivery to tumor cells has led to investigations into the administration of magnetic drugs, which use magnetic fields to target treatment to specific organs, thereby reducing side effects compared to traditional treatments. The dynamics of MTD in breast arteries are currently unknown and can be modeled using second-order differential equations. Blood flow is generally assumed to be a non-Newtonian fluid due to its viscosity characteristics. In this study, we modeled the targeting efficiency of magnetic nanoparticles with sizes of 50 nm, 100 nm, and 200 nm under a constant magnetic field of 0.12 T using a computational tool based on the finite element technique. Our results showed that magnetic nanoparticle targeting efficiency was highest with simulated magnetic fields located 5 cm, 7.5 cm, and 15 cm away from the tumor when using nanoparticles of 50 nm and 100 nm.
Funder
Universidad Distrital Francisco Jose de Caldas
Publisher
Springer Science and Business Media LLC
Subject
Condensed Matter Physics,General Materials Science,Modeling and Simulation,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering
Reference37 articles.
1. Alexiou C, Arnold W, Klein RJ, Parak FG, Hulin P, Bergemann C, Erhardt W, Wagenpfeil S, Lubbe AS (2002) Locoregional cancer treatment with magnetic drug targeting. Cancer Res 60(23):6641–6648
2. Alexiou C, Schmidt A, Klein R, Hulin P, Bergemann C, Arnold W (2002) Magnetic drug targeting: biodistribution and dependency on magnetic field strength. J Magn Magn Mater 252(1-3 SPEC. ISS): 363-366. https://doi.org/10.1016/S0304-8853(02)00605-4-11
3. Berry CC, Curtis ASG (2003) Functionalisation of magnetic nanoparticles for applications in biomedicine. J Phys D Appl Phys 36(13). https://doi.org/10.1088/0022-3727/36/13/203
4. Grief AD, Richardson G (2005) Mathematical modelling of magnetically targeted drug delivery. J Magn Magn Mater 293(1):455–463. https://doi.org/10.1016/j.jmmm.2005.02.040
5. Nacev A, Beni C, Bruno O, Shapiro B (2011) The behaviors of ferromagnetic nano-particles in and around blood vessels under applied magnetic fields. J Magn Magn Mater. https://doi.org/10.1016/j.jmmm.2010.09.008
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