Common variable immunodeficiency and the gastrointestinal tract

Author:

Kalha Ishaan,Sellin Joseph H.

Publisher

Springer Science and Business Media LLC

Subject

Gastroenterology,General Medicine

Reference40 articles.

1. Hammarstrom L, Vorechovsky I, Webster D: Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID). Clin Exp Immunol 2000, 120:225–131.

2. Cunningham-Rundles C, Bodian C: Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin Immunol 1999, 92:34–48. In this study, 248 consecutive patients were followed for a period of up to 25 years. The mean age of diagnosis was 23 years in males and 28 years in female patients. Parameters found to be associated with mortality were lower levels of serum IgG, poor T-cell response, and a low proportion of peripheral B cells, which was statistically significant.

3. McCabe RP, Washington K, Stenzel TT, et al.: Gastrointestinal manifestations of non-AIDS immunodeficiency. Curr Treat Options Gastroenterol 2002, 5:17–25. This article discusses the manifestations of CVID and gives a good overview of the other primary immunodeficiencies. It discusses defects in antigen presentation and the relationship between phagocytic diseases and Crohn’s disease.

4. Saiki O, Ralph P, Cunningham-Rundles C, et al.: Three distinct stages of B-cell defects in common varied immunodeficiency. Proc Natl Acad Sci U S A 1982, 79:6008–6012.

5. Lai Ping So A, Mayer L: Gastrointestinal manifestations of primary immunodeficiency disorders. Semin Gastrointest Dis 1997, 8:22–32. This review article outlines the definition, pathophysiology, and clinical presentation of CVID in the gastrointestinal tract. It divides the clinical disorders into either inflammatory or infectious etiology. It summarizes the risk of malignancy and the therapeutic options available for treating CVID.

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