Intestinal Mesenchymal Cells

Author:

Pinchuk I. V.,Mifflin R. C.,Saada J. I.,Powell D. W.

Publisher

Springer Science and Business Media LLC

Subject

Gastroenterology,General Medicine

Reference51 articles.

1. • Andoh A, Bamba S, Brittan M, et al.: Role of intestinal subepithelial myofibroblasts in inflammation and regenerative response in the gut. Pharmacol Ther 2007, 114:94–106. This comprehensive review of myofibroblast biology covers the cytokine/chemokine networks, cascades, and receptors expressed by intestinal myofibroblast. The focus on IL-22, IL-23, IL-17, and the proinflammatory cyokines as well as secretion of matrix modifying molecules such as the matrix metalloproteinases (MMPs) and their specific tissue inhibitors (TIMPs) indicate the potential role for these cells in inflamatory bowel disease pathogenesis.

2. • Powell DW, Pinchuk IV, Saada JI, et al.: Mesenchymal cells of the intestinal lamina propria. Annu Rev Physiol 2011, in press. This review is an expanded and more detailed version covering many of the issues discussed briefly in this present Current Gastroenterology Reports article.

3. •• Furuya S, Furuya K: Subepithelial fibroblasts in intestinal villi: roles in intercellular communication. Int Rev Cytol 2007, 264:165–223. This is an outstanding review of the anatomy and biology of intestinal myofibroblasts from an entirely different perspective than the information in this Current Gastroenterology Report. This review by the Furuyas deals with, among other aspects, the mechanosensitive properties of myofibroblasts and how they act as a gap junction and adherens junction-connected network, contracting in response to purinergic and endothelial agonists.

4. Adegboyega PA, Mifflin RC, DiMari JF, et al.: Immunohistochemical study of myofibroblasts in normal colonic mucosa, hyperplastic polyps, and adenomatous colorectal polyps. Arch Pathol Lab Med 2002, 126:829–836.

5. Powell DW, Adegboyega PA, Di Mari JF, Mifflin RC: Epithelial cells and their neighbors I. Role of intestinal myofibroblasts in development, repair, and cancer. Am J Physiol Gastrointest Liver Physiol 2005, 289:G2–G7.

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