The role of cyclooxygenase selective inhibitors in the gastrointestinal tract-Reference-Cited by-同舟云学术

The role of cyclooxygenase selective inhibitors in the gastrointestinal tract

Published:2003-12 Issue:6 Volume:5 Page:453-458
ISSN:1522-8037
Container-title:Current Gastroenterology Reports
language:en
Short-container-title:Curr Gastroenterol Rep

Author:

Cryer Byron

Publisher

Springer Science and Business Media LLC

Subject

Gastroenterology,General Medicine

Link

http://link.springer.com/content/pdf/10.1007/s11894-003-0033-7.pdf

Reference26 articles.

1. O’Banion MK, Sadowski HB, Winn V, Young DA: A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein. J Biol Chem 1991, 266:23261–23267.

2. Wallace JL, McKnight W, Reuter B, Vergnolle N: NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology 2000, 119:706–714. This study provided the first observation suggesting that inhibition of COX-1 and COX-2 is necessary to cause GI ulceration. Thus, the reason that COX-2 inhibitors may be associated with improved GI safety may be related to not inhibiting both COX isoforms rather than to simply inhibiting only COX-2 in the GI tract.

3. Riendeau D, Percival MD, Brideau C, et al.: Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. J Pharmacol Exp Ther 2001, 296:558–566.

4. Lanza FL, Rack MF, Simon TJ, et al.: Specific inhibition of cyclooxygenase-2 with MK-0966 is associated with less gastroduodenal damage than either aspirin or ibuprofen. Aliment Pharmacol Ther 1999, 13:761–767.

5. Emery P, Zeidler H, Kvien TK, et al.: Celecoxib versus diclofenac in long-term management of rheumatoid arthritis: randomised double-blind comparison. Lancet 1999, 354:2106–2111.

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