Management of small intestinal bacterial overgrowth

Author:

Van Citters Gregg W.,Lin Henry C.

Publisher

Springer Science and Business Media LLC

Subject

Gastroenterology,General Medicine

Reference15 articles.

1. Pimentel M, Soffer EE, Chow EJ, Lin HC: Lower frequency of MMC is found in IBS subjects with abnormal lactulose breath test, suggesting bacterial overgrowth. Dig Dis Sci 2002, 47:2639–2643. This paper describes reduced frequency of intestinal housekeeper waves in patients with IBS who have confirmed SIBO.

2. Pimentel M, Chow EJ, Lin HC: Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am J Gastroenterol 2000, 95:3503–3506.

3. Pimentel M, Chow EJ, Lin HC: Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome a double-blind, randomized, placebocontrolled study. Am J Gastroenterol 2003, 98:412–419. This double-blind, placebo-controlled study of IBS sufferers compared treatment with neomycin to placebo. LBT was performed before and after treatment. Neomycin treatment resulted in normalization of LBT and decreased symptoms nearly three times more than placebo. Methane production was related to severity of constipation. Rapid transit was not a factor in producing elevated breath gas or symptoms because both diarrhea-predominant and constipation-predominant IBS sufferers had similar LBT profiles.

4. Tillman R, King C, Toskes P: Continued experience with the xylose breath test: evidence that the small bowel culture as the gold standard for bacterial overgrowth may be tarnished. Gastroenterology 1981, 80:1304.

5. Harmsen HJ, Gibson GR, Elfferich P, et al.: Comparison of viable cell counts and fluorescence in situ hybridization using specific rRNA-based probes for the quantification of human fecal bacteria. FEMS Microbiol Lett 2000, 183:125–129.

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