Cryptogenic Multifocal Ulcerating Stenosing Enteropathy(CMUSE) and/or Chronic Non-specific Multiple Ulcers of the Small Intestine(CNSU) and Non-granulomatous Ulcerating Jejunoileitis (NGUJI)

Author:

Singh Ayaskanta

Publisher

Springer Science and Business Media LLC

Subject

Gastroenterology,General Medicine

Reference55 articles.

1. Debray C, Besancon F, Hardouin JP, Martin E, Marche C, Khoury K. Cryptogenetic plurifocal ulcerative stenosing enteritis. Arch Mal Appar Dig Mal Nutr. 1964;53:193–206.

2. • Perlemuter G, Guillevin L, Legman P, Weiss L, Couturier D, Chaussade S. Cryptogenetic multifocal ulcerous stenosing enteritis: an atypical type of vasculitis or a disease mimicking vasculitis. Gut. 2001;48:333–8. Initial paper which gives a comprehensive review and also tries to explain the pathogenesis of CMUSE.

3. • Matsumoto T, Iida M, Matsui T, Yao T. Chronic nonspecific multiple ulcers of the small intestine: a proposal of the entity from Japanese gastroenterologists to Western enteroscopists. Gastrointest Endosc. 2007;66(3 Suppl):S99–S107. The term CNSU is coined in Japan.

4. •• Umeno J, Hisamatsu T, Esaki M, Hirano A, Kubokura N, Asano K, et al. A hereditary enteropathy caused by mutations in the SLCO2A1 gene, encoding a prostaglandin transporter. PLoS Genet. 2015;11(11):e1005581. Landmark paper where the genetic basis of the disease is identified and the term CEAS is coined.

5. •• Hosoe N, Ohmiya N, Hirai F, Umeno J, Esaki M, Yamagami H, et al. Chronic enteropathy associated with SLCO2A1 gene [CEAS]—characterisation of an enteric disorder to be considered in the differential diagnosis of Crohn’s disease. J Crohn’s Colitis. 2017;11(10):1277–81. https://doi.org/10.1093/ecco-jcc/jjx068 . Large multicentric study from Japan, where 20 patients of CEAS are described. Validates that CNSU are autosomal recessive and occur due to mutation in the SLCO2A1 gene.

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