Screening for Malignancy in Primary Sclerosing Cholangitis (PSC)
Author:
Publisher
Springer Science and Business Media LLC
Subject
Gastroenterology,General Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11894-015-0438-0.pdf
Reference30 articles.
1. Boonstra K, Beuers U, Ponsioen CY. Epidemiology of primary sclerosing cholangitis and primary biliary cirrhosis: a systematic review. J Hepatol. 2012;56(5):1181–8. doi: 10.1016/j.jhep.2011.10.025 . A systemic search of literature was performed in MEDLINE and EMBASE for population-based epidemiological studies reporting incidence and/or prevalence rates for PSC or PBC. Literature yielded 2286 abstracts of which 31 articles fulfilled inclusion critieria. Overall the authors concluded that incidence and prevalence rates of both PSC and PBC vary widely and seem to be increasing.
2. Fevery J, Henckaerts L, Van Oirbeek R, et al. Malignancies and mortality in 200 patients with primary sclerosing cholangitis: a long-term single-centre study. Liver Int. 2012;32(2):214–22. doi: 10.1111/j.1478-3231.2011.02575.x . Two hundred patients with PSC were followed to analyze morbidity and mortality. Malignancies developed in 20% of which 45.9% led to death.
3. Bergquist A, Ekbom A, Olsson R, et al. Hepatic and extrahepatic malignancies in primary sclerosing cholangitis. 2002;36:321–7.
4. Zenouzi R, Weismüller TJ, Hübener P, et al. Low risk of hepatocellular carcinoma in patients with primary sclerosing cholangitis with cirrhosis. Clin Gastroenterol Hepatol. 2014;12(10):1733–8. doi: 10.1016/j.cgh.2014.02.008 . This is a retrospective study of patients with well-defined PSC. Data were collected from periods of up to 33 years. 119 patients with cirrhosis were identified. During 292 patient-years, none of these patients developed HCC.
5. Soetikno RM, Lin OS, Heidenreich PA, Young HS, Blackstone MO. Increased risk of colorectal neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis: a meta-analysis. Gastrointest Endosc. 2002;56(1):48–54. doi: 10.1067/mge.2002.125367 .
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