Cholesterol and Radiosensitivity
Author:
Funder
National Institutes of Health
Publisher
Springer Science and Business Media LLC
Subject
Oncology
Link
http://link.springer.com/content/pdf/10.1007/s12609-016-0202-y.pdf
Reference57 articles.
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2. Butt S et al. The target for statins, HMG-CoA reductase, is expressed in ductal carcinoma-in situ and may predict patient response to radiotherapy. Ann Surg Oncol. 2014;21:2911–9. doi: 10.1245/s10434-014-3708-4 . This paper provides clinically relevant evidence demonstrating that the main target of statins, HMGCR, is highly expressed in early stage breast cancer and predicts response to radiation therapy. Data strongly supports HMCGR as a biomarker of response to radiation therapy alone or in combination with statins.
3. Stewart FA et al. Ionizing radiation accelerates the development of atherosclerotic lesions in ApoE−/− mice and predisposes to an inflammatory plaque phenotype prone to hemorrhage. Am J Pathol. 2006;168:649–58. doi: 10.2353/ajpath.2006.050409 .
4. Rosenson RS et al. Dysfunctional HDL and atherosclerotic cardiovascular disease. Nat Rev Cardiol. 2015. doi: 10.1038/nrcardio.2015.124 .
5. Reiner Z. Management of patients with familial hypercholesterolaemia. Nat Rev Cardiol. 2015;12:565–75. doi: 10.1038/nrcardio.2015.92 .
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