1. Burget DW, Chiverton SG, Hunt RH: Is there an optimal degree of acid suppression for healing of duodenal ulcers: A model of the relationship between ulcer healing and acid suppression. Gastroenterology
99:345–351, 1990. It is the duration that the intragastric pH is above 3 that is important for DU healing: it is not necessary to achieve more potent acid inhibition.
2. Johnston DA, Marks IN, Young GO, et al: Duodenal ulcer healing and acid secretory responses to modified sham feeding and pentagastrin stimulation. Aliment Pharmacol Ther
4:403–410, 1990. DU healing with sucralfate results in decreased acid secretory responses to vagal and pentagastrin stimulation.
3. Jones DB, Howden CW, Burget DW, el al: Acid suppression in duodenal ulcer: A meta-analysis to define optimal dosing with antisecretory drugs. Gut
28:1120–1127, 1987. The duration of acid suppression is important to predict the rate of DU healing after varying periods of treatment.
4. Kummer AF, Johnston DA, Marks IN, et al: Changes in nocturnal and peak acid outputs after duodenal ulcer healing with sucralfate or ranitidine. Gut
33:175–178, 1992. Acid secretion in DU patients falls after ulcer healing is achieved by healing with either of these medications.
5. Savarino V, Mela GS, Zentilin P, et al: Lack of gastric acid rebound after stopping a successful shortterm course of Nizatidine in duodenal ulcer patients. Am J Gastroenterol
86:281–284, 1991. Acid rebound may not be the problem that it was once thought to be—at least not with this H2-receptor antagonist.