Successful theory development in biology: A consideration of the theories of oxidative phosphorylation proposed by Davies and Krebs, Williams and Mitchell

Author:

Prebble John N.1

Affiliation:

1. Royal Holloway University of London, Egham, Surrey TW20 0EX, England.

Abstract

The chemiosmotic theory is normally attributed to Peter Mitchell's formulation published in Nature in 1961. However, the essential elements of the theory were published 9 years earlier by Davies and Krebs. Why, then, was this earlier formulation overlooked? The success of Mitchell's theory is examined in comparison with those of Davies and Krebs and of Williams.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference41 articles.

1. Allchin, D. (1990) Paradigms, population and problem-fields: approaches to disagreement.Philosophy of Science Association biennial symposium; Minneapolis, MN, USA. Vol. 1, pp. 53?66.

2. Gilbert, G. N. and Mulkay, M. (1984)Opening Pandora's box. Cambridge University Press, Cambridge.

3. Kuhn, T. S. (1970)The structure of scientific revolutions Univ. Chicago Press, Second edition. See Chapter 7.

4. Mitchell, P. (1961) Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism.Nature 191:144?148.

5. Letter to the editor of Nature, 28 April 1961.

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