Peptide histidine valine-42 stimulates gastric acid secretion in man-Reference-Cited by-同舟云学术

Peptide histidine valine-42 stimulates gastric acid secretion in man

Published:1989-06-01 Issue:3 Volume:9 Page:369-374
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Nikou G. C.¹,Yiangou Y.¹,Chrysanthou B. J.¹,Domin J.¹,Bloom S. R.¹

Affiliation:

1. Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 ONN, UK

Abstract

The effect of peptide histidine valine-42 (PHV-42) on gastric acid secretion was studied in man. PHV-42 was infused into 5 healthy volunteers at a dose of 10 pmol/kg/min. This dose caused a significant stimulation of basal gastric acid and potassium output. there were no significant changes in circulating gastrin throughout the infusion. In 2 subjects with a background of submaximal pentagastrin stimulation, PHV-42 infusion at the same dose did not alter acid secretion in either subject. The previous observation that PHV-42 is found particularly in the stomach and the new finding that it stimulates basal gastric secretion suggest the possibility that PHV-42 could have a role in local control of acid secretion.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/9/3/369/472351/bsr0090369.pdf

Reference16 articles.

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2. Itoh, N., Obata, K.-i., Yanaihara, N. and Okamoto, H. (1983) Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27,Nature 304:547?549.

3. Yiangou, Y., Christofides, N. D., Blank, M. A., Yanaihara, N., Tatemoto, K., Bishop, A. E., Polak, J. M. and Bloom, S. R. (1985) Molecular forms of peptide histidine isoleucine-like immunoreactivity in the gastrointestinal tract.Gastroenterology 89:516?524.

4. Yiangou, Y., Requejo, F., Polak, J. M. and Bloom, S. R. (1986) Characterisation of a novel prepro VIP derived peptide.Biochem. Biophys. Res. Commun. 139:1142?1149.

5. McGregor, G. P., Bishop, A. E., Blank, M. A., Christofides, N. D., Yiangou, Y., Polak, J. M. and Bloom, S. R. (1984) Comparative distribution of vasoactive intestinal polypeptide (VIP), substance P and PHI in the enteric sphincters of the cat.Experientia 40:469?471.

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