Overexpression of SerpinB9 in non-seminomatous germ cell tumors

Author:

Anami Toshiki,Ibe Yuki,Li Lianbo,Komohara YoshihiroORCID,Hirao Hiroki,Harada Mamoru,Yano Hiromu,Fujiwara Yukio,Motoshima Takanobu,Yatsuda Junji,Hibi Taizo,Kamba Tomomi

Funder

Japan Society for the Promotion of Science London

Publisher

Springer Science and Business Media LLC

Subject

Molecular Biology,General Medicine,Pathology and Forensic Medicine

Reference19 articles.

1. Cathomas R, Lorch A, Bruins HM, Compérat EM, Cowan NC, Efstathiou JA, Fietkau R, Gakis G, Hernández V, Espinós EL, Neuzillet Y, Ribal MJ, Rouanne M, Thalmann GN, van der Heijden AG, Veskimäe E, Alfred Witjes J, Milowsky MI (2022) The 2021 Updated European Association of Urology Guidelines on Metastatic Urothelial Carcinoma. Eur Urol 81:95–103

2. Rini BI, Battle D, Figlin RA, George DJ, Hammers H, Hutson T, Jonasch E, Joseph RW, McDermott DF, Motzer RJ, Pal SK, Pantuck AJ, Quinn DI, Seery V, Voss MH, Wood CG, Wood LS, Atkins MB (2019) The society for immunotherapy of cancer consensus statement on immunotherapy for the treatment of advanced renal cell carcinoma (RCC). J Immunother Cancer 7:354

3. Klein B, Klein T, Konichezky M, Nyska A, Livini E, Levine I, Zamir R, Kooperman O, Lurie H (1990) The expression of HLA class I antigens in germ cell testicular cancer. Am J Clin Pathol 93:202–207

4. Medema JP, de Jong J, Peltenburg LT, Verdegaal EM, Gorter A, Bres SA, Franken KL, Hahne M, Albar JP, Melief CJ, Offringa R (2001) Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors. Proc Natl Acad Sci USA 98:11515–11520

5. Ibáñez-Molero S, van Vliet A, Pozniak J, Hummelink K, Terry AM, Monkhorst K, Sanders J, Hofland I, Landeloos E, Van Herck Y, Bechter O, Kuilman T, Zhong W, Marine JC, Wessels L, Peeper DS (2022) SERPINB9 is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade response. Oncoimmunology 11:2139074

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