Assay of tipranavir capsules by a simple stability-indicating LC–UV method and cytotoxicity study of degraded samples

Author:

Somavilla Leila P.,Lago Matheus W.,Barth Patrícia O.,Nogueira-Librelotto Daniele R.,Rolim Clarice M. B.,Adams Andréa I. H.ORCID

Funder

CNPq

Publisher

Springer Science and Business Media LLC

Subject

Materials Chemistry,Industrial and Manufacturing Engineering,General Chemical Engineering,Biochemistry,General Chemistry

Reference30 articles.

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2. Busacca CA, Campbell S, Saha A, Lorenz JC, Grozinger K, Jones PJ, Grinberg N, Shen S, Lee H, Qiu F, Granger A, Yuabova Z, Norwood D, Senanayake CH (2005) Structure elucidation and total synthesis of a unique group of trace impurities in Tipranavir® drug product. Magn Reson Chem 43(12):1032–1039. https://doi.org/10.1002/mrc.1672

3. Chen S, Dudhedia MS, Wang Z, Darrington RT, Tamblyn T, Smoliga JA, Jones PJ, Krill SL (2009) Drug-excipient complexation in lipid based delivery systems: an investigation of the tipranavir-1,3-dioctanolyglycerol complex. J Pharm Sci 98:1732–1743. https://doi.org/10.1002/jps.21542

4. Choi SO, Rezk NL, Kashuba ADM (2007) High-performance liquid chromatography assay for the determination of the HIV-protease inhibitor tipranavir in human plasma in combination with nine other antiretroviral medications. J Pharm Biomed Anal 43(4):1562–1567. https://doi.org/10.1016/j.jpba.2006.11.017

5. Crommentuyn KML, Rosing H, Hillebrand MJX, Huitema ADR, Beijnen JH (2004) Simultaneous quantification of the new HIV protease inhibitors atazanavir and tipranavir in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. J Chromatogr B 804(2):359–367. https://doi.org/10.1016/j.jchromb.2004.01.041

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