Pre- and post-diagnostic dairy intake in relation to recurrence and all-cause mortality in people with stage I-III colorectal cancer
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Published:2023-07-02
Issue:7
Volume:62
Page:2891-2904
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ISSN:1436-6207
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Container-title:European Journal of Nutrition
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language:en
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Short-container-title:Eur J Nutr
Author:
van Lanen Anne-SophieORCID, Kok Dieuwertje E., Wesselink Evertine, Winkels Renate M., van Halteren Henk K., de Wilt Johannes H. W., Kampman Ellen, van Duijnhoven Fränzel J. B.
Abstract
Abstract
Purpose
Higher dairy consumption is associated with a lower risk of colorectal cancer (CRC), but no studies thus far have investigated its relation with recurrence in CRC. Few studies have investigated total dairy in relation to mortality in CRC, and yielded inconsistent results.
Methods
In this prospective cohort study, people newly diagnosed with stage I-III CRC filled out a food frequency questionnaire at diagnosis (n = 1812) and six months after diagnosis (n = 1672). We examined associations between pre- and post-diagnostic intake of total dairy, low-fat dairy, high-fat dairy, milk, yoghurt, and cheese with recurrence and all-cause mortality using multivariable Cox proportional hazard models and restricted cubic splines (RCS).
Results
A total of 176 recurrences and 301 deaths occurred during a median follow-up of 3.0 and 5.9 years, respectively. Before diagnosis, a higher low-fat dairy intake was associated with a lower risk of recurrence (HRQ4vsQ1: 0.42, 95% CI 0.26–0.67; PRCS: 0.008) and all-cause mortality (HRQ4vsQ1: 0.58, 95% CI 0.41–0.81; PRCS < 0.001), whereas a higher high-fat dairy consumption tended to be associated with an increased all-cause mortality risk (HRQ4vsQ1: 1.41, 95% CI 0.98–2.01; PRCS: 0.030). After diagnosis, only the associations between low- and high-fat dairy in relation to all-cause mortality remained.
Conclusions
This study demonstrated that higher pre- and post-diagnostic intakes of low-fat dairy were associated with a reduced all-cause mortality risk in people with stage I-III CRC, whereas higher intakes of high-fat dairy were associated with an increased all-cause mortality risk. Also, a higher pre-diagnostic low-fat dairy intake was associated with a reduced risk of recurrence.
Trial registration
Clinical Trials.gov identifier: NCT03191110.
Funder
Regio Deal Foodvalley Wereld Kanker Onderzoek Fonds (WKOF) & World Cancer Research Fund International World Cancer Research Fund International Alpe d’Huzes/Dutch Cancer Society TRANSCAN: Dutch Cancer Society
Publisher
Springer Science and Business Media LLC
Subject
Nutrition and Dietetics,Medicine (miscellaneous)
Reference38 articles.
1. Jin S, Kim Y, Je Y (2020) Dairy consumption and risks of colorectal cancer incidence and mortality: a meta-analysis of prospective cohort studies. Cancer Epidemiol Biomarkers Prev 29(11):2309–2322. https://doi.org/10.1158/1055-9965.Epi-20-0127 2. World Cancer Research Fund/American Institute for Cancer Research (2018) Diet, nutrition, physical activity and colorectal cancer 3. Norat T, Riboli E (2003) Dairy products and colorectal cancer. A review of possible mechanisms and epidemiological evidence. Eur J Clin Nutr 57(1):1–17. https://doi.org/10.1038/sj.ejcn.1601522 4. World Cancer Research Fund/American Institute for Cancer Research (2018) Diet, nutrition, physical activity and cancer: a global perspective 5. Dik VK, Murphy N, Siersema PD, Fedirko V, Jenab M, Kong SY, Hansen CP, Overvad K, Tjønneland A, Olsen A, Dossus L, Racine A, Bastide N, Li K, Kühn T, Boeing H, Aleksandrova K, Trichopoulou A, Trichopoulos D, Barbitsioti A, Palli D, Contiero P, Vineis P, Tumino R, Panico S, Peeters PH, Weiderpass E, Skeie G, Hjartåker A, Amiano P, Sánchez MJ, Fonseca-Nunes A, Barricarte A, Chirlaque MD, Redondo ML, Jirström K, Manjer J, Nilsson LM, Wennberg M, Bradbury KE, Khaw KT, Wareham N, Cross AJ, Riboli E, Bueno-de-Mesquita HB (2014) Prediagnostic intake of dairy products and dietary calcium and colorectal cancer survival–results from the EPIC cohort study. Cancer Epidemiol Biomarkers Prev 23(9):1813–1823. https://doi.org/10.1158/1055-9965.Epi-14-0172
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