Abstract
Abstract
Purpose
High-fat, high-calorie (HFHC) diets have been used as a model to investigate lipid-induced insulin resistance. Short-term HFHC diets reduce insulin sensitivity in young healthy males, but to date, no study has directly compared males and females to elucidate sex-specific differences in the effects of a HFHC diet on functional metabolic and cardiovascular outcomes.
Methods
Eleven males (24 ± 4 years; BMI 23 ± 2 kg.m−2; V̇O2 peak 62.3 ± 8.7 ml.min−1.kg−1FFM) were matched to 10 females (25 ± 4 years; BMI 23 ± 2 kg.m−2; V̇O2 peak 58.2 ± 8.2 ml.min−1.kg−1FFM). Insulin sensitivity, measured via oral glucose tolerance test, metabolic flexibility, arterial stiffness, body composition and blood lipids and liver enzymes were measured before and after 7 days of a high-fat (65% energy) high-calorie (+ 50% kcal) diet.
Results
The HFHC diet did not change measures of insulin sensitivity, metabolic flexibility or arterial stiffness in either sex. There was a trend towards increased total body fat mass (kg) after the HFHC diet (+ 1.8% and + 2.3% for males and females, respectively; P = 0.056). In contrast to females, males had a significant increase in trunk to leg fat mass ratio (+ 5.1%; P = 0.005).
Conclusion
Lean, healthy young males and females appear to be protected from the negative cardio-metabolic effects of a 7-day HFHC diet. Future research should use a prolonged positive energy balance achieved via increased energy intake and reduced energy expenditure to exacerbate negative metabolic and cardiovascular functional outcomes to determine whether sex-specific differences exist under more metabolically challenging conditions.
Funder
Society for Endocrinology
Publisher
Springer Science and Business Media LLC
Subject
Nutrition and Dietetics,Medicine (miscellaneous)
Reference59 articles.
1. Kearney J (2010) Food consumption trends and drivers. Philos Trans R Soc Lond B Biol Sci 365(1554):2793–2807. https://doi.org/10.1098/rstb.2010.0149
2. Townsend N, Bhatnagar P, Wickramasinghe K, Scarborough P, Foster C, Rayner M (2012) Physical activity statistics 2012. British Heart Foundation, London
3. British Heart Foundation (2017) Physical inactivity Report 2017. https://www.bhf.org.uk/informationsupport/publications/statistics/physical-inactivity-report-2017
4. Katzmarzyk PT (2010) Physical activity, sedentary behavior, and health: paradigm paralysis or paradigm shift? Diabetes 59(11):2717–2725. https://doi.org/10.2337/db10-0822
5. Naja F, Hwalla N, Itani L, Karam S, Sibai AM, Nasreddine L (2015) A Western dietary pattern is associated with overweight and obesity in a national sample of Lebanese adolescents (13–19 years): a cross-sectional study. Br J Nutr 114(11):1909–1919. https://doi.org/10.1017/S0007114515003657
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