Assessment of the antidiabetic activity of epicatechin in streptozotocin-diabetic and spontaneously diabetic BB/E rats-Reference-Cited by-同舟云学术

Assessment of the antidiabetic activity of epicatechin in streptozotocin-diabetic and spontaneously diabetic BB/E rats

Published:1985-03-01 Issue:3 Volume:5 Page:215-221
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

bone A. J.¹,Hii C. S. T.²,Brown D.¹,Smith W.¹,Howell S. L.²

Affiliation:

1. Metabolic Unit, Western General Hospital, Edinburgh, U.K.

2. Department of Physiology, Queen Elizabeth College, London W8 7AH, U.K.

Abstract

(−)-Epicatechin has previously been suggested to rapidly reverse alloxan diabetes in rats. We have assessed the therapeutic value of the compound in two further animal models of insulin-dependent diabetes mellitus, namely streptozotocin – diabetic rats and the spontaneously diabetic BB/E rat. There was no indication of a reversal of established diabetes in either the streptozotocin-diabetic or the spontaneously diabetic BB/E rats. Moreover, epicatechin also failed to halt the progression of the disease in prediabetic BB/E rats. Earlier claims of the potential use of epicatechin as an antidiabetic agent must therefore be treated with some caution.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/5/3/215/471246/bsr0050215.pdf

Reference12 articles.

1. Chakravarthy BK, Gupta S, Gamblir SS & Gode KD (1980) Ind. J. Pharmac.12, 123?127.

2. Chakravarthy BK, Gupta S, Gamblir SS & Gode KD (1981) Lancetii, 759?760.

3. Chakravarthy BK, Gupta S & Gode KD (1982) Life Sci.31, 2693?2697.

4. Dyrberg T, Nakhooda AF, Baekkeskov S, Lernmark A, Poussier P & Marliss EB (1982) Diabetes31, 278?281.

5. Hii CST & Howell SL (1984a) Diabetes33, 291?296

Cited by 30 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Clinical applications and mechanism insights of natural flavonoids against type 2 diabetes mellitus;Heliyon;2024-05

2. In Silico Analysis of PTP1B Inhibitors and TLC-MS Bioautography-Based Identification of Free Radical Scavenging and α-Amylase Inhibitory Compounds from Heartwood Extract of Pterocarpus marsupium;ACS Omega;2022-12-09

3. The Role of Catechins in Regulating Diabetes: An Update Review;Nutrients;2022-11-04

4. Mechanisms Underlying the Antidiabetic Activities of Polyphenolic Compounds: A Review;Frontiers in Pharmacology;2021-12-14

5. Moroccan antidiabetic medicinal plants: Ethnobotanical studies, phytochemical bioactive compounds, preclinical investigations, toxicological validations and clinical evidences; challenges, guidance and perspectives for future management of diabetes worldwide;Trends in Food Science & Technology;2021-09