Author:
Olanrewaju Adesoji A.,Oke David G.,Adekunle David O.,Adeleke Olufeyikemi A.,Akinola Omowumi T.,Emmanuel Abiodun V.,Oyeneyin Oluwatoba E.
Abstract
AbstractThree new Schiff bases, (Z)-2-(4-(dimethylamino)benzylidene)-N-methylhydrazinecarbothioamide (PDM), (Z)-2-(2-hydroxy-5-nitrobenzylidene)-N-methylhydrazinecarbothioamide (5NS) and (Z)-2-(4-cyanobenzylidene)-N-methylhydrazinecarbothioamide (4CN) of thiosemicarbazone-benzaldehyde derivatives were synthesized by condensation reaction. These compounds were formed from the reaction of 4-methyl-3-thiosemicarbazide with p-dimethylaminobenzaldehyde, 5-nitrosalicylaldehyde and 4-formylbenzonitrile respectively. The molecules synthesized were screened against bacterial isolates; Gram-positive (Staphylococcus aureus and Bacillus cereus), and Gram-negative (Klebsiella pnuemoniae and Pseudomonas aeruginosa) bacteria using agar well diffusion technique, supported by molecular docking and theoretical analysis through computational approach adopting a coupled DFT-B3LYP and 6-31G(d) basis set. The in-vitro antibacterial studies proofed that the compounds have a broad-spectrum antibacterial activity against the bacterial isolates while 5NS (21.0 mm) and PDMA (9.5 mm) have higher antibacterial activities than the standard drug, streptomycin against Staphylococcus aureus (16.5 mm) and Pseudomonas aeruginosa (9.0 mm) respectively. Theoretical studies and molecular docking established the fact that these Schiff bases could be explored further as bioactive compounds against bacterial infections and also as corrosion inhibitors of metals in the oil and gas industry.
Graphical abstract
Publisher
Springer Science and Business Media LLC
Subject
General Earth and Planetary Sciences,General Physics and Astronomy,General Engineering,General Environmental Science,General Materials Science,General Chemical Engineering
Reference44 articles.
1. Wang X, Ding G, Duan Y, Zhu Y, Zhu G, Wang M, Li X, Zhang Y, Qin X, Hung CH (2020) A novel triphenylamine-based bis-Schiff bases fluorophores with AIE-activity as the hydrazine fluorescence turn-off probes and cell imaging in live cells. Talanta 217:121029. https://doi.org/10.1016/j.talanta.2020.121029
2. Sadia M, Khan J, Naz R, Zahoor M, Shah SWA, Ullah R, Sohaib M et al (2021) Schiff base ligand L synthesis and its evaluation as anticancer and antidepressant agent. J King Saud Univ-Sci 33(2):101331
3. Abu-Dief AM, Mohamed IM (2015) A review on versatile applications of transition metal complexes incorporating Schiff bases. Beni-suef Univ J Basic Appl Sci 4(2):119–133
4. Przybylski P, Huczynski A, Pyta K, Brzezinski B, Bartl F (2009) Biological properties of schiff bases and azo derivatives of phenols. Curr Org Chem 13(2):124–148
5. Siddique M, Saeed AB, Dogar NA, Ahmad S (2013) Biological potential of synthetic hydrazide based Schiff bases. J Sci Innov Res 2:651–657
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献