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4. Slotman B, Faivre-Finn C, Kramer G, Rankin E, Snee M, Hatton M, et al. Prophylactic cranial irradiation in extensive small-cell lung cancer. N Engl J Med. 2007;357:664–72. This randomised phase III study shows a survival benefit of PCI for ED-SCLC.
5. Seto T, Takahashi T, Yamanaka T, Harada H, Nokihara H, Saka H, et al. Prophylactic cranial irradiation (PCI) has a detrimental effect on the overall survival (OS) of patients (pts) with extensive disease small cell lung cancer (ED-SCLC): Results of a Japanese randomized phase III trial. J Clin Oncol ASCO Ann Meet Abstr. 2014;32:7503. This randomised phase III study fails to demonstrate a survival benefit of PCI for ED-SCLC.