Promising New Agents for Colorectal Cancer
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Oncology
Link
http://link.springer.com/article/10.1007/s11864-018-0543-z/fulltext.html
Reference45 articles.
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3. Mayer R, Van Cutsem E, Falcone A, et al. Randomized trial of TAS-102 for refractory metastatic colorectal cancer. N Engl J Med. 2015;372:1909–19.
4. Grothey A, Van Cutsem E, Sobrero A, et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. 2013;381(9863):303–12.
5. •• Overman M, McDermott R, Leach J, et al. Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study. Lancet Oncol. 2017;18(9):1182–91. A proof of concept trial which led to the approval of nivolumab in MSI-high cancers after standard chemotherapy approaches, and furthermore, in mCRC patients post exposure to oxaliplatin and irinotecan. Beyond the ORR demonstrated with the single-agent therapy, the duration of response demonstrated by responding patients was striking.
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