HPV as a Carcinomic Driver in Head and Neck Cancer: a De-escalated Future?
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Oncology
Link
https://link.springer.com/content/pdf/10.1007/s11864-022-00950-8.pdf
Reference34 articles.
1. Tota JE, Best AF, Zumsteg ZS, Gillison ML, Rosenberg PS, Chaturvedi AK. Evolution of the oropharynx cancer epidemic in the United States: moderation of increasing incidence in younger individuals and shift in the burden to older individuals. J Clin Oncol. 2019;37(18):1538–46.
2. Mahal BA, Catalano PJ, Haddad RI, et al. Incidence and demographic burden of HPV-associated oropharyngeal head and neck cancers in the United States. Cancer Epidemiol Biomarkers Prev. 2019;28(10):1660–7.
3. Ang KK, Harris J, Wheeler R, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010;363(1):24–35.
4. •• Yom SS, Torres-Saavedra P, Caudell JJ, et al. Reduced-dose radiation therapy for HPV-associated oropharyngeal carcinoma (NRG Oncology HN002). J Clin Oncol. 2021;39(9):956–65 This is a report of NRG HN002 which evaluated definitive chemoradiotherapy to 60 Gy with or without concurrent cisplatin in patients with low-risk HPV-associated oropharyngeal tumors. Their paper found excellent results with 60 Gy and concurrent cisplatin which is currently an investigational arm in the ongoing NRG HN005.
5. Ferris RL, Flamand Y, Weinstein GS, et al. Transoral robotic surgical resection followed by randomization to low- or standard-dose IMRT in resectable p16+ locally advanced oropharynx cancer: a trial of the ECOG-ACRIN Cancer Research Group (E3311). J Clin Oncol. 2020;38(15_suppl):6500–0.
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