Obesity and Metabolic Syndrome Among Adult Survivors of Childhood Leukemia

Author:

Gibson Todd M.,Ehrhardt Matthew J.,Ness Kirsten K.

Funder

National Institutes of Health

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Oncology

Reference68 articles.

1. Pui CH, Evans WE. A 50-year journey to cure childhood acute lymphoblastic leukemia. Semin Hematol. 2013;50(3):185–96. doi: 10.1053/j.seminhematol.2013.06.007 .

2. Mody R, Li S, Dover DC, Sallan S, Leisenring W, Oeffinger KC, et al. Twenty-five-year follow-up among survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. Blood. 2008;111(12):5515–23. doi: 10.1182/blood-2007-10-117150 .

3. Armstrong GT, Kawashima T, Leisenring W, Stratton K, Stovall M, Hudson MM, et al. Aging and risk of severe, disabling, life-threatening, and fatal events in the childhood cancer survivor study. J Clin Oncol. 2014;32(12):1218–27. doi: 10.1200/JCO.2013.51.1055 .

4. Armstrong GT, Oeffinger KC, Chen Y, Kawashima T, Yasui Y, Leisenring W, et al. Modifiable risk factors and major cardiac events among adult survivors of childhood cancer. J Clin Oncol. 2013;31(29):3673–80. doi: 10.1200/JCO.2013.49.3205 . This study documents the multiplicative risk of obesity, hypertension, dyslipidemia, and diabetes on cardiovascular disease among childhood cancer survivors exposed to known cardiotoxic treatment exposures.

5. Smith WA, Li C, Nottage KA, Mulrooney DA, Armstrong GT, Lanctot JQ, et al. Lifestyle and metabolic syndrome in adult survivors of childhood cancer: a report from the St. Jude Lifetime Cohort Study. Cancer. 2014;120(17):2742–50. doi: 10.1002/cncr.28670 . This paper describes the protective effects of a healthy lifestyle (diet, physical activity) on the development of metabolic syndrome among childhood cancer survivors, even in the presence of past cranial radiation exposure.

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